Arboviruses transmission of emerging and reappearing viruses is a major global risk to human and veterinary health. Mosquito bites transmit a virus to humans. The virus can then spread to other humans through bites through infected mosquitoes. Aedes aegypti and Aedes albopictus mosquitos usually spread the chikungunya virus. These are the same dengue-transmitting mosquitoes. The prevention and control of mosquito breeding depend heavily on reducing the number of natural and artificial water-filled container habitats. This demands that the affected communities be mobilized.
Researchers observed a Chikungunya-infected mosquito, which originated from Africa in 2013 and first found in the U.S. No vaccine is available for virus prevention or treatment, and while fever and joint pain are the most common symptoms, they may be severe and disabling. The scientists have used three separate microscopes of the electron, beginning with the midgut or stomach to view the virus traveling through the mosquito. The first two microscopes had two-dimensional views of a single tissue layer in the stomach of the mosquito. The third, an electron microscope focused on the ion beam enabled researchers to see multiple tissue layers.
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The effort was funded by the National Institutes of Health-National Institute of Allergy and Infectious Diseases and the University of Missouri award for “Excellence in Electron Microscopy.” The content is the sole task of the authors and not necessarily the official views of the financial agencies. Researchers at the University of Missouri can now, by using state-of-the-art technology, learn how a virus moves inside the body of a mosquito that can stop them from transmitting the virus. The study was concluded successfully with the guidance of Alexander Franz and the corresponding author of the studies, an assistant professor in the Department of Veterinary Pathology at the MU University of Veterinary Arts.
In the conclusion of the study, with a futuristic view, researchers hope that one day, they will inhibit the genes involved, in order to prevent future transmission of mosquito-borne diseases, from the release of the virus within its stomach. This study is the first publication by means of the focussed ion beam electron microscope purchased by the MU Research Office at the University of Missouri in 2016.