HEALTHCARE TECHNOLOGY KNOWLEDGE NETWORK$15HEALTHCARETECHOUTLOOK.COMEUROPE SPECIALONCOLOGY EDITIONDECEMBER - 14 - 2023ISSN 2691 - 3933New Paradigm in Cancer Drug DiscoveryVidac Pharma% Complex intact Dissociation of VDAC/HK2 complex (MST assay)HK2 dissociation IC50 = 0.09 MVDA-1102 does not affect hexokinase 1 (HK1), therefore has no effect on normal cellsApoptosis Triggered (Cleaved caspase-3 in cells)031030050100150200250V D A - 1 10 2, m MCleaved Caspase 3 RU% Cleaved Caspase 3 RU% VDA-1102, µMhSCC A431 cells, 6 hours of Tx; ELISADATA: Selective HK2 Detachment & Apoptosis
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