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Innovative technologies are advancing the progress of analytical methods for characterizing complicated drugs and vaccines.
FREMONT, CA: Researchers at the Institute for Bioscience and Biotechnology Research (IBBR) has bagged $1.1 million from the Food and Drug Administration (FDA) and the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL). The funds raised is used to advance the progress of analytical methods for characterizing complicated drugs and vaccines. Vaccines, antibodies, and other top-selling therapeutics are made up of complicated biomolecules like proteins and nucleic acids. Biomanufacturing such products comprise of lengthy and expensive production, along with refinement, and packaging processes. Not only are the ultimate products sophisticated, but the complete biomanufacturing process is complicated and delicate, all of which require the use of unconventional instrumentation skilled of advanced measurements to monitor the validate and process the ultimate product.
Prevailing measurements require contact with the biomanufacturing solution that proposes additive sampling steps and chances of contamination. Ongoing quality control methods also need opening a subset of vials from every batch, making conclusions about comprehensive batches based on those measurements. Yu's lab is pioneering the practice of water proton nuclear magnetic resonance (wNMR) spectroscopy for biomanufacturing applications. With NIIMBL' s assistance, Yu's group, along with scientists from vaccine teams at Merck & Co. Inc. and Pfizer Inc., is adapting their flow wNMR processes for monitoring the production and stabilit
y of vaccine-adjuvant complexities during biomanufacturing.
IBBR is a joint research company that is backed financially in part by the University of Maryland Strategic Partnership: MPowering the State, an action intended to deliver innovation and impact via collaboration. The Institute resides at the nexus of academic research plus commercial application that brings essential elements together required to spur transformative discoveries in the field of biotechnology. This field provides novel solutions to significant scientific and engineering challenges important to society. IBBR researchers endeavor to improve the areas of disease pathways and biomolecular measurement sciences, biomolecular targets, and biomolecular engineering, comprising of structure-based design of therapeutics and vaccines.
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