Scientists have developed next-gen materials that activate wound healing with the help of tissues.
FREMONT, CA: The increasing number of surgical site infections gives rise to the development of new surgical procedures in the U.S. Chronic wounds caused by diabetes do not heal quickly and often surface the wound with a wide range of bacteria in the form of biofilm. Biofilm bacteria are very tough to treat, and the antimicrobial resistance only stimulates the possibility of an infection in the wound.
According to recent statistics, chronic wounds tend to affect over 5 million people approximately in the U.S. A few chronic wounds caused by diabetic ulcers might end up in amputations. Researchers have predicted that a chronic, non-healing diabetic ulcer leads to an amputation every 30 seconds.
There is an immediate need for innovative as well as effective wound healing techniques to overcome the situation. Scientists have devised a molecule that can help in harnessing the natural healing process of the body. These molecules, known as traction force-activated payloads (TrAPs), are the growth factors that contribute materials like collagen that heals the wound by interacting with the body tissues naturally.
Materials like collagen are mostly employed to heal wounds. An example would be collagen sponges that are used to treat burn injuries and its implants that could help in regenerating bones. During interacting with the tissues, in the supposed scaffold implants, the cells migrate throughout the collagen structure while pulling the scaffold. The method then stimulates the healing proteins, which are the growth factors helping in regenerating tissues.
The TrAP molecules can also be devised to recreate the natural processes. The cells drag the TrAPs along with them as they start migrating via the collagen implants, leading to the stimulation of growth proteins that activate the healing process within the tissue. This technique shows how natural healing processes recreated. Also, the approach imitates them and actively works with different kinds of cells on the damaged tissue, eventually, to help in healing.
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