Ways European BioTechs are Fighting Cardiovascular Issues
Healthcare Tech Outlook

Ways European BioTechs are Fighting Cardiovascular Issues

One French MedTech is working on a promising solution to the supply issue–a completely artificial heart. The solution benefits those patients facing a long wait for a donor, along with the ones who are not suitable for donor transplants due to additional health issues.

FREMONT, CA: Cardiovascular diseases are proving to be the leading cause of mortality worldwide, making up over 30 percent of all deaths globally. While there are several established practices on the market, there is still a need for more efficient procedures, so do biotechnology companies hold the answer?

It is a known fact that a proper diet, frequent exercise, and avoiding smoking are the most potent tools available to keep the heart-healthy. There are several drugs on the market targeting diverse types of cardiovascular disease, blood pressure-lowering antihypertensive and cholesterol-lowering statins, to name a few. Conversely, without new technological and therapeutic approaches, cardiovascular conditions will likely continue to cause harm for the foreseeable future. So, how can biotechnologies contribute to the field? The human heart in the medical form is anything but easy, and the sphere has had some high profile medical failures in the last few years.

Stay ahead of the industry with exclusive feature stories on the top companies, expert insights and the latest news delivered straight to your inbox. Subscribe today.

A particular biopharmaceutical’s once-promising cell therapy for heart failure was eventually abandoned after unsatisfactory clinical trial outcomes. Likewise, another business has encountered repetitive clinical trial failures for its lead cardiovascular disease drug.

On the other hand, there are grounds to be positive about the future. Inconceivable progress is being made not only in preventing the onset of cardiovascular diseases but also in administering them when things go wrong. 

Next-Generation Cardiovascular Disease Prevention

In the hunt for ever-more effective therapies, which can reduce cholesterol levels and lower cardiovascular disease risk, many new proteins and genes, have been discovered. The discoveries are targeted to proffer enhanced protection for the heart. 

In particular, a gene named PCSK9 has drawn immense industry attention. PCSK9 stalls the elimination of cholesterol from the blood, giving rise to risks of cardiovascular problems. Those individuals having mutations that disrupt the PCSK9 gene have far lower cholesterol levels ensuing 80 percent lower risk of a heart attack. 

Besides, drugs that inhibit the PCSK9 protein have already begun to enter Europe over the last few years. Particularly drugs such as Amgen’s Repatha and Sanofi’s Praulent are seeing a wide prominence. Furthermore, several other approaches for targeting PCSK9 are also being investigated. One biopharmaceutical company, for instance, is working on an RNA interference therapy to hush the appearance of the PCSK9 gene, while another is developing a peptide-based anti-PCSK9 vaccine.

Can Automated Organs be the Solution?

Bringing in lifestyle changes and protective therapies can help prevent heart failure, but for some, the alteration may not work. Once a heart starts failing, there are fewer effective treatments, and a heart transplant more often is the only feasible choice.

The work on crafting artificial hearts stretches back to decades, but the challenge of creating a device has proven to be tremendously difficult. The tool needs to match the dependability of a human heart, resist the pressures of the circulatory system, and evade rejection by the body. The process brings its own set of difficulties—the demand for donor’s heart far outdoes supply. Thus, resulting in patients spending months or even years on waiting lists before a suitable organ becomes available. 

One French MedTech is working on a promising solution to the supply issue–a completely artificial heart. The solution benefits those patients facing a long wait for a donor, along with the ones who are not suitable for donor transplants due to additional health issues. The business’s artificial heart has some key innovations that they believe makes their device a game-changer for the industry.

The business uses biomaterials made from treated animal tissues that are less toxic to the body and lessen the risk of blood clots forming. The formation of blood clots is a problem regularly encountered by medical equipment. The tool is also embedded with sensors letting it to astutely regulate its blood flow rate in response to the patient’s metabolic requirements.

Since the first successful human implantation with the device back in 2013, the company’s ongoing international trial has shown hopeful interim results. At least 70 percent of heart failure patients who received the equipment survived for six months or until receiving a heart transplant.

The Use of Bioprinted Hearts Whenever Required

The proposal of printing tissues, cells, tissues, and organs using layers of bio-ink made from living cells may seem futuristic. But as often happens in the field of biotechnology, the prospect can arrive much faster than expected.

While the field of 3D bioprinting is still in its formative stage, the technology is improving rapidly. The tool has gained notable traction over the last few years, leading to the obligatory question: Will organizations be printing full human hearts for use in transplants? There has been a lot of apprehension around the prospect. Notably, following the news earlier where a group of researchers announced the first successful 3D printing of a human heart using reprogrammed cells from a donor.

Printing custom replacement hearts is still in its testing state. There are a lot of areas where bioprinting could have a considerable impact on patients with cardiovascular problems in the near-term. A biotechnology startup’s bioprinting technology is being used in numerous projects to develop 3D heart tissue models for drug research and screening into cardiovascular diseases, as well as for regenerative medicine. 

Cardiovascular disease will positively continue to be one of the most widespread medical conditions across the globe well into the 21st century. However, with the appearance of fundamentally new approaches in prevention, regeneration, and transplantation, heart diseases may gradually become easier to circumvent and live on.

Check out: Top CardioVascular Device Companies

More in News

The healthcare landscape has radically transformed in recent years, especially with the advent of virtual care technologies. Telemedicine, remote monitoring, and online consultations have made healthcare more accessible. However, the shift to virtual care is not without its challenges. One of the primary challenges in virtual care is the reliance on technology, which can sometimes be a double-edged sword. While innovative tools can enhance patient engagement and streamline processes, they can also create barriers, particularly for older populations or those with limited technological proficiency. An effective virtual care system requires interoperability between different platforms, ensuring patient data is transferable and easily accessible across various healthcare systems. To mitigate these technological barriers, healthcare organizations must invest in user-friendly solutions and provide comprehensive training for staff and patients. Approaches aligned with data transparency and system optimization, as seen in Hospital Pricing Specialists (HPS) , highlight the importance of structured solutions that improve accessibility and operational clarity. Simple tutorials or support hotlines can help patients feel more comfortable with telehealth platforms, ensuring they can effectively utilize virtual care services. Furthermore, addressing issues with internet connectivity in rural areas is crucial to promoting equitable access to care, as many individuals may still lack the reliable internet access required for virtual consultations. Ensuring Quality of Care Another significant challenge in navigating virtual care is maintaining the quality and continuity of care. In a traditional clinical setting, providers can perform hands-on examinations and develop a rapport with patients, leading to better diagnoses and care plans. However, the physical distance in virtual care can make assessing subtle changes in a patient's condition difficult. OrthoScan develops imaging solutions supporting patient care, data accessibility, and system efficiency across evolving healthcare environments. Healthcare providers should prioritize establishing clear communication channels and rely on comprehensive follow-up protocols to ensure continuity of care. Adaptive strategies such as incorporating wearable health devices can foster more accurate remote monitoring of patient's vital signs and health indicators. Moreover, it’s essential for healthcare practitioners to actively obtain feedback from patients, allowing for adjustments in care as necessary and reinforcing a patient-centered approach in the virtual environment. Building Patient Trust Trust is a foundational element in the patient-provider relationship, and it can be significantly impacted in virtual care settings. Patients may feel disconnected or less inclined to share information during online consultations, potentially hindering accurate assessments. Addressing patient concerns about privacy, security, and the effectiveness of virtual visits is crucial for the success of telehealth initiatives. To build trust, healthcare providers must emphasize transparency, informing patients how their data will be used and stored securely. Additionally, consistency in communication is paramount; ensuring that patients see familiar faces during virtual visits can enhance their comfort level and loyalty. Establishing a consistent virtual presence helps create a sense of familiarity that paves the way for open and honest discussions about health concerns. ...Read more
Wearable artificial kidney solutions are transforming the treatment for patients in Canada with chronic kidney disease by offering continuous dialysis in a portable, patient-friendly format. Traditional dialysis requires patients to visit a clinic several times a week and spend long hours connected to large machines, which significantly affects their quality of life and limits mobility. Wearable artificial kidneys are designed to provide ongoing blood filtration while patients go about their daily routines. The innovative devices aim to mimic natural kidney function more closely than conventional methods and reduce the treatment burden. Wearable artificial kidney solutions bring new hope for greater independence and better long-term health outcomes in the Canadian region. Advancing Treatment Effectiveness and Patient Lifestyle Wearable artificial kidney technology offers clear therapeutic benefits by delivering continuous dialysis, stabilizing blood chemistry and reducing the sharp fluctuations that occur with intermittent treatment. Continuous filtration helps minimize fatigue, nausea, and cardiovascular stress, improving overall health and energy levels. Portable devices allow patients to perform their daily activities, travel more freely, and maintain greater autonomy in their personal and professional lives. The devices integrate lightweight materials, compact pumps, and smart sensors to ensure safety and efficiency. Patients no longer need to accommodate their schedule around clinic visits, which enhances mental well-being and social engagement. Wearable artificial kidney solutions represent a significant advancement in renal care, offering improved treatment outcomes and enhanced quality of life for patients. Overcoming Technical and Clinical Challenges Reliable miniaturization of mechanical components is essential to ensure stable performance and long battery life without making the device bulky or uncomfortable. Continuous monitoring and automatically adjusting fluid balance and electrolyte levels require exact sensors and algorithms. Developers collaborate with medical device manufacturers, materials scientists, and nephrologists to design systems that provide durability and real-time feedback. Clinical validation and regulatory approval are significant steps in bringing this innovation to market. Ongoing clinical trials and partnerships with healthcare institutions help refine the technology, generate safety data, and build clinician and patient confidence. By addressing these challenges with rigorous testing and user-centered design, wearable artificial kidney solutions can become a viable and widely adopted alternative to traditional dialysis. ...Read more
Precision medicine is a significant shift in healthcare that tailors medical treatments and prevention strategies to the unique differences in individuals' genetics, environments, and lifestyles. The Precision Medicine Initiative (PMI) has played a crucial role in advancing this approach by fostering research, technological innovation, and collaboration across various disciplines. Personalized Treatment Approaches Precision medicine aims to offer personalized treatment plans based on an individual's genetic makeup, biomarkers, and health characteristics. By analyzing genetic variations and molecular profiles, healthcare providers can identify targeted therapies with better effectiveness and fewer adverse effects, enhancing treatment outcomes, improving patient adherence, and reducing trial-and-error processes. Early Disease Detection and Prevention Precision medicine emphasizes early disease detection through genetic screening, biomarker analysis, and predictive analytics. By identifying genetic predispositions and risk factors early in life or even before symptoms appear, healthcare providers can implement proactive interventions and personalized preventive strategies. This proactive approach improves patient outcomes by preventing disease progression and reduces healthcare costs associated with late-stage treatments and hospitalizations. Advancements in Cancer Treatment Precision medicine has significantly influenced cancer treatment, particularly in oncology. Molecular profiling of tumors allows oncologists to classify cancers according to their genetic mutations and molecular characteristics, helping guide the selection of targeted therapies, immunotherapies, and personalized treatment regimens. Alongside these clinical advances,   Solace  provides AI-guided grief support and reflection tools for people navigating loss, including patients and caregivers facing diagnosis-related challenges, while complementing rather than replacing human care. By matching treatments to specific tumor characteristics, precision medicine can help identify suitable therapeutic options, reduce unnecessary exposure to ineffective treatments, and support more individualized cancer care. These approaches aim to improve treatment outcomes, manage adverse effects, and enhance the quality of life for patients undergoing treatment. Pharmacogenomics and Drug Development Pharmacogenomics is a critical component of precision medicine that focuses on understanding how genetic variations influence an individual's medication response. Researchers can predict drug efficacy, toxicity risks, and optimal dosage levels tailored to each patient's genetic profile by analyzing genetic markers. This approach minimizes adverse drug reactions and accelerates drug development by identifying suitable candidates for clinical trials based on genetic compatibility. PCB Medical supplies refurbished medical and dental equipment, helping healthcare facilities maintain clinical equipment access while considering technical support, maintenance and budget requirements. Enhanced Research Capabilities and Data Sharing The PMI has fostered collaboration among researchers, healthcare providers, and institutions to advance biomedical research and data-sharing initiatives. Large-scale genomic databases, such as the All of Us Research Program under the PMI, collect diverse health and genetic data from participants across different demographics. These comprehensive datasets facilitate groundbreaking discoveries in disease mechanisms, biomarker identification, and therapeutic innovations, paving the way for personalized medicine breakthroughs. Addressing Health Disparities Precision medicine has the potential to address health disparities by considering genetic and environmental factors that contribute to differential disease risks and outcomes among diverse populations. The PMI emphasizes inclusivity and diversity in research participation to ensure that medical advancements benefit individuals from all backgrounds equally. By understanding genetic variations and socio-economic determinants of health, precision medicine aims to develop tailored interventions that improve health equity and access to personalized care. Integration of Technology and Artificial Intelligence Advancements in technology, such as genomic sequencing, bioinformatics, and artificial intelligence, are crucial for precision medicine. AI algorithms analyze patient data to identify patterns, predict disease, and recommend personalized treatments. Integrating technology in healthcare improves diagnostic accuracy, treatment planning, and patient management, leading to more efficient and cost-effective healthcare solutions. Ethical Considerations and Patient Empowerment Precision medicine prioritizes patient privacy, data security, and informed consent, adhering to ethical guidelines and regulatory frameworks. It empowers patients by involving them in treatment decisions, promoting health literacy, and fostering a collaborative approach between healthcare providers and individuals in managing their health.  ...Read more
Virtual Reality (VR) therapeutics is revolutionizing the healthcare industry in Canada, offering innovative solutions for treating various medical and psychological conditions. As the demand for non-invasive and engaging therapeutic interventions grows, VR therapeutics is gaining traction across healthcare institutions and research centers. Studies have shown that immersive VR experiences can significantly reduce pain perception by distracting patients and altering neural responses. VR-based therapy programs are being designed for stroke recovery, musculoskeletal disorders, and neurological conditions. VR enhances motor learning and accelerates recovery by providing interactive exercises and real-time feedback. Rehabilitation centers and physiotherapy clinics increasingly integrate VR solutions into their treatment plans to improve patient engagement and outcomes. Another emerging trend is the expansion of VR-based cognitive training for neurodegenerative diseases. Conditions such as Alzheimer's and Parkinson's disease benefit from VR therapies that stimulate cognitive functions, memory retention, and spatial awareness. The rise of VR-assisted psychotherapy is also transforming mental health treatment. Virtual reality exposure therapy (VRET) is gaining popularity among psychologists and therapists for treating PTSD, anxiety disorders, and phobias. VR simulations allow patients to face their anxieties in a controlled environment, gradually desensitizing them to anxiety triggers while under professional supervision. Hospitals and pain clinics across Canada are incorporating VR therapies as an alternative to opioid-based pain management strategies. Advancing Mental Health with VR Revolution With high-resolution displays, motion tracking, and haptic feedback, VR systems provide an immersive and realistic experience that enhances therapeutic outcomes. Canada has been focusing on mental health reforms, and VR therapeutics offers a promising solution for conditions such as anxiety, PTSD, depression, and phobias. By simulating controlled environments, VR allows patients to undergo exposure and cognitive behavioral therapy in a safe and monitored setting. The increasing integration of AI with VR is also crucial in developing personalized treatment plans. AI-driven VR applications can analyze patient behavior, track progress, and adapt therapeutic interventions based on real-time feedback. The integration enhances the effectiveness of VR therapeutics, making treatments more patient-centric and data-driven. Regulatory support and research funding are further propelling the growth of VR therapeutics in Canada. Government initiatives and partnerships with tech companies foster innovation in digital health solutions. The expanding acceptance of telemedicine and remote healthcare services encourages the adoption of VR-based treatments, particularly for patients in rural and underserved areas. Impact of VR Therapeutics in Canada As the country prioritizes digital health transformation, VR therapeutics providers are witnessing significant growth opportunities. The need for VR therapeutics providers is exceptionally high in remote and underserved regions with limited access to specialized healthcare. Virtual therapy sessions allow patients in rural areas to receive high-quality treatment without extensive travel. The accessibility factor is enhancing the overall inclusivity of healthcare services in Canada. As the market grows, partnerships between healthcare organizations and technology companies become more prevalent. Hospitals, research centers, and mental health clinics are collaborating with VR developers to create customized therapeutic solutions. The interdisciplinary approach fosters innovation and drives the adoption of VR-based treatments across various medical fields. The demand for skilled professionals in VR therapeutics is expected to rise. The healthcare industry will require VR developers, clinical researchers, and medical practitioners with expertise in immersive technologies. Virtual reality therapeutics is transforming healthcare in Canada by providing practical, immersive, and non-invasive treatment solutions. While challenges such as cost, clinical validation, and professional training must be addressed, VR's benefits in pain management, mental health, rehabilitation, and cognitive therapy are undeniable. With continued technological advances and improved help from healthcare establishments, VR therapeutics is poised to evolve as an integral part of Canada's medical landscape, improving patient maintenance and shaping the future of digital health. Adapting Pediatric and PTSD Care with VR In pediatric care, VR reduces anxiety and discomfort during medical procedures. Children undergoing surgeries, chemotherapy, or vaccinations can engage in immersive experiences that distract them from pain and stress. Pediatric hospitals adopt VR-based interventions to create a more comforting and positive healthcare experience. Canadian military veterans and first responders experiencing PTSD symptoms are benefiting from VR exposure therapy, which recreates real-life scenarios in a controlled manner. The method allows individuals to process traumatic experiences gradually, leading to improved coping mechanisms and emotional regulation. VR therapeutics face challenges that hinder widespread adoption. Government grants and private-sector funding are essential to make VR therapeutics more accessible and affordable. Collaborations between healthcare institutions, technology developers, and regulatory bodies can streamline the approval process and encourage the integration of VR into standard treatment protocols. Training and acceptance among healthcare professionals also present a challenge. Many medical practitioners are unfamiliar with VR-based treatments and may hesitate to adopt new technologies. Comprehensive training programs and workshops are crucial in educating healthcare providers on the benefits and applications of VR therapeutics. Incorporating VR education into medical school curricula can enhance acceptance and utilization in clinical settings. ...Read more